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In this wacky year, the Big Ten conference will have 12 teams and the Big 12 will have only ten after the departure of Colorado and Nebraska. The Big 12 landscape will change significantly without those two. Here is an early look at the college football betting odds for who in the Big 12 has the best chance to win the 2012 national championship.

The Oklahoma Sooners top the list as the most likely team in the nation to go all the way this year with 2012 BCS championship odds of +370. The dynamic passing duo of quarterback Landry Jones and Ryan Broyles will be back, along with linebacker Travis Lewis and four starters on the offensive line.

The 9th ranked Oklahoma Sooners and 13th ranked Nebraska Cornhuskers will meet this weekend in the final Big 12 championship game before Nebraska moves to the Big Ten. Both teams finished the season 10-2, with Oklahoma coming off a very impressive victory over in state rival Oklahoma State to get into this game. Nebraska is a six point underdog in the college football lines.

In one of the premier games of the college football season, the 9th ranked Oklahoma State Cowboys host the 13th ranked Oklahoma Sooners for a spot in the Big 12 championship game. Led by their two powerful offenses, these teams have in essence a one game playoff. Both teams are coming off wins, with the Cowboys knocking off Kansas and the Sooners beating Baylor. The Cowboys are a 2.5 point favorite in the college football odds.

Two of the remaining undefeated teams in the nation, including the BCS rankings leading Oklahoma Sooners, meet this week in a Big 12 showdown. The Sooners travel to face the Missouri Tigers, currently ranked 11th in the BCS standings. Both teams are 6-0 and are coming off blowout victories. Oklahoma handled Iowa State 52-0 and the Tigers beat Texas A&M 30-9. The Sooners are a three point favorite in the college football lines.

Top 25 teams from the Big 12 collide this Saturday as the 8th ranked Oklahoma Sooners take on the 21st ranked Texas Longhorns. While these two teams don’t look as powerful as they have been in the past, there are sure to be plenty of fireworks in the 105th meeting between these programs.

Texas will try to rebound after a shocking loss to UCLA, 34-12.The Sooners defeated Cincinnati 31-29, their third victory by seven points or less this season. The college football odds have Oklahoma as a 3.5 favorite.

The Oklahoma Sooners defense has not had an easy start to their schedule. After facing multi-faceted Utah State, they took on pass happy Florida State. After winning both of those games, they play the top ranked rushing team in the country, the Air Force Falcons.

The Falcons are also off to a 2-0 start, beating rival BYU last week 35-14. The seventh ranked Sooners looked excellent in their last game, destroying the Seminoles 47-17. When the Falcons visit the Sooners this weekend, the college football odds have them as a 17 point underdog.

Norman, Oklahoma will be the site of a major top 25 matchup in the second week of college football. The Oklahoma Sooners take on the Florida State Seminoles in a battle that will have far reaching implications.

The Florida State Seminoles blew out their first opponent, Samford, by a score 59-6. Oklahoma on the other hand, had their hands full and narrowly beat Utah State 31-24. Oklahoma is a 9.5 point favorite in college football lines.

2009 Total Offense Rank (yards per game): 23
2009 Total Defense Rank (yards per game): 8

The Oklahoma Sooners had a rough 2009 season. Losing quarterback Sam Bradford early in the year crippled the team, and forced them to suffer through an up and down season. The Sooners lost a lot of talent from last year’s squad, including Bradford, defensive tackle Gerald McCoy and offensive tackle Trent Williams (3 of the top 4 picks in the draft).